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Showing content with the highest reputation on 02/26/2021 in all areas

  1. 7 points
  2. 5 points
  3. 4 points
    I haven't been following everything in the conversation here, so I may repeat some points that have already been made. It's certainly the case, especially in hindsight, that testing and approval could have gone more quickly. There are a few things worth noting, however: 1) a much more rapid approval process could have greatly undermined public confidence - in the case of the US, even a slightly more rapid approval process could have undermined confidence, because of concerns approval was being rushed in time for the election 2) even though development of the vaccine was extremely rapid, it's worth noting that bulk manufacturing still takes time to scale up - the companies began much of that process immediately and even so have had difficulties meeting manufacturing targets - the capacity to make tens of millions of doses of an mRNA vaccine didn't yet exist last spring or summer 3) Russia and China have enormous control over their media and therefore their governments have more breathing room to "rush" vaccine approvals, and even so they didn't do so until around August, if I recall correctly It's true that there was very good reason to believe that the mRNA vaccines would be safe (theoretical considerations and animal testing), and also good reason to believe they would at least be reasonably effective. But a rushed approval process would have left them more open to people doubting them when side effects inevitably occurred, and I think the doubt and backlash, combined with limited initial availability, means we might not have come out ahead in the long run. It's possible that by the time the proper scientific results were in and the vaccine was actually widely available, you'd have a large portion of the population resistant to being vaccinated. (There is precedent for this: the 1976 swine flu vaccine wasn't actually a harmful vaccine, but the public perception that it had been rushed and that adverse events following the vaccine were caused by it, is believed to be one of the root causes for a fall in vaccination rates beginning in the 1980s.) I do hope that in the future, the success of the mRNA technology means that vaccine rollouts for any novel diseases will occur more quickly. There's also the possibility we'll be able to do better against existing diseases, such as responding much more rapidly to new flu strains using mRNA vaccines, thereby making the seasonal flu shot more effective. Most of the time, milder new strains of a disease tend to outcompete more deadly strains. In the long term, that's what's expected to happen with COVID, but it's not necessarily the case that will be happening right now. Mutations that either increase and decrease the virulence (severity) of a virus happen all the time. The effect this has on transmissibility though is complicated - a mutation that increases viral replication will generally increase both severity of the disease and viral loads, which you might imagine would increase transmissibility. However, more severe disease is more likely to disable (or even kill) the host before transmission occurs. So a balancing act occurs, where the most successful strains of a pathogen are the ones that are able find the optimal zone where replication is fast enough to outcompete slower replicating strains but not so fast that the host is disabled or killed before transmission occurs. That optimal zone is a moving target - in conditions that favour rapid transmissions (susceptible host population, crowding etc.), a virus that replicates fast and disables the host quickly will often outcompete less virulent strains. However, in conditions where spread is slowed down (for example, most potential hosts are immune), a less virulent strain will outcompete more virulent strains because it has more time to reach a susceptible host. So in the longer term, pathogens (at least in vertebrates, who have adaptive immunity) usually evolve to cause milder disease as immunity in the population reaches a high level. However, I don't think we're there yet with COVID, and there's some evidence to suggest some of the new strains may cause somewhat more severe disease. I mention this to clarify what I imagine some people may percieve as conflicting information, I do expect that in the long term COVID will cause milder disease than it does now, even among unvaccinated/unexposed individuals.
  4. 3 points
  5. 3 points
    I'm a science teacher. I did a graduate degree in the area of evolutionary biology and my undergrad major was biochemistry. (so I also had courses in molecular genetics and immunology, which are highly related fields - at my alma mater those majors were collectively referred to as "BIG", for biochemistry, immunology, and genetics)
  6. 3 points
  7. 3 points
    Worth noting that Red tier here means 25% capacity, so basically what it was when TENET came out.
  8. 2 points
  9. 2 points
    Jajajaja, thanks. I've been lurking the China BO thread recently but with BO dead in your own region there's just not the same motivation. Still nice to see that you and many of the regulars are still around!
  10. 2 points
    Yeah, orange would be better, and yellow better yet. However NYC is also just 25% iirc and that seems to be getting covered pretty much as “NYC starts to reopen.” 25% isn’t that limiting either, when the marketplace is so dead that you can give like 70% of screens to one movie if it needs them. But yeah. Baby steps. 👍
  11. 1 point
    Raya still isn't listed on Village Cinemas for me so may have to also find a Hoyts one.
  12. 1 point
    Still not listed on Event Cinemas website and less than a week to release, looks like I'm going to Hoyts to watch this one. At least it will be a nice treat to visit my childhood cinema which I haven't been to since I watched Disaster Artist there a few years ago, but will become very annoying quickly if all Disney movies are only at Hoyts cinemas going forward.
  13. 1 point
    If anyone is looking for a last minute movie to watch before they submit their ballots may i point you this direction
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  16. 1 point
    I don't think anyone liked T&J tho tbf. Seems like another Scoob!.
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  18. 1 point
    "Hi, mom" has reached the $700m figure, so the all time list showdown between China and DOM is right now: China vs DOM 1. Wolf Warrior 2 ($880m) vs TFA ($936m) 2. Ne Zha ($777m) vs Avengers - Endgame ($858m) 3. The Wandering Earth ($720m) vs Avatar ($760m) 4. Hi, mom: $704m vs Black Panther ($700m) 5. Avengers - Endgame ($657m) vs Avengers - Infinity War ($678m) This is the first time that one certain spot in the all time list is bigger in China than in DOM. When Hi, mom and DC3 had finished their runs, this situation should happen to spots #3, #4 and #5. We can maybe see something like this: China vs DOM 1. Wolf Warrior 2 ($880m) vs TFA ($936m) 2. Hi, mom ($810m) vs Avengers - Endgame ($858m) 3. Ne Zha ($777m) vs Avatar ($760m) 4. The Wandering Earth ($720m) vs Black Panther ($700m) 5. Detective Chinatown 3 ($690m) vs Avengers - Infinity War ($678m) Chinese figures are obtained with current ERs
  19. 1 point
  20. 1 point
    Panama/Central America another 5.5M for a total of 71M in 12 markets. $272M. There's another $4M reported by Disney giving total LatAm a total of $276M, so 72M admits. Mexico - 34% BR - 27% Rest - 38%
  21. 1 point
    My mom got her first shot this Tuesday. Hearing a lot more anecdotes now. Haven’t been posting daily updates as diligently this week because it’s all pretty borked by the Texas/coldsnap correction, like I warned on Sunday. Hosp continues around 2.5% down a day, roughly looking at 3 weeks to 30k at this rate. That’s good since it’s much more robust to data disruption, but it’s also a bit of a lagging indicator compared to cases — if cases were actually on an uptrend that would be very bad even if hosp were still dropping. The more unqualified good news is that the positive % continues to decline.
  22. 1 point
    The sheet, for reference: Looks like 66M Latam, about 40% Mexico, 30% Brazil, 30% rest.
  23. 1 point
  24. 1 point
    LA is the key to all of this For reference, current guidelines in CA are that theaters can reopen when a county moves to Red level. LA needs about a 40% further drop in infections, which might happen in a matter of weeks.
  25. 1 point
    Thank you, so many points I struggle to find the words are explained by you in the typical for you so much ore clear fashion than I manage to do so (I think I botched up a few tries). So much better... ❤️
  26. 1 point
    @CayomMagazine New Journey Pictures Classics has acquired a Regina King directed film titled Grace and Mercy which stars Tiffany Haddish as a dance instructor who suffers from a highly-publicized miscalculation involving gorilla glue. Based on true events.
  27. 1 point
    You completely missed the point of this movie. It isn't a horror movie lmao. It's a meta-comedy, kinda like Scream but with more comedy, more gore, and less horror.
  28. 1 point
    2016 2016 was a year dominated by animation, even by Chilean standards, with a whopping 41,7% of market share. Ice Age 5 topped the year with a decrease from the previous entry but facing heavy competition from 2 animated juggernauts: Finding Dory and the Secret Life of Pets. The cut for the top 10 was Batman vs Superman with 902k, still the highest cut-off to this date. Total Admissions: 27.659.999 (+6,2%) Number of Screens: 378 Top Movie: Ice Age Collision Course (1.522.936) Over 1m: 6; Ice Age 5, Finding Dory (1,5m), Secret Life of Pets (1,3m), Sin Filtro (1,2m), Captain America: Civil War (1,2m), The Conjuring (1,1m) Also notable: Sin Filtro is the last local movie that managed to be a legit hit. 2017 2017 managed to squeak a very tiny increase but for the first time in a decade, the BO was "stagnant" despite screens growing by almost 10%. Fittingly enough, this year also saw another phenomenon not seen in decades, not since Titanic actually: Coco. With an astonishing 21x multiplier in admissions, Coco actually grossed more in 2018 than in 2017. It was still at the top of the Box Office on its eleventh weekend and finally claimed the all-time crown in March, almost four months after its release. It stayed more than 6 months in multiplexes, longer than any other movie on record. One can just dream what would have happened if it swapped release dates with Cars 3... Total Admissions: 27.744.674 (+0,2%) Number of Screens: 410 Top Movie: Coco (2.234.951) Over 1m: 6; Coco, Despicable Me 3 (1,6m), It (1,2m), Fast and Furious 8 (1,2m), Moana (1,1m), The Boss Baby (1m) Also notable: The Boss Baby also had impressive legs, coming out of nowhere to the million mark. The failure of Cars 3 at winter's holidays is amazing, just 690k admissions for a well-known franchise and the Pixar brand with one of the lowest multipliers ever for animation. 2018 Overall stagnation continued over 2018, which would have in fact decreased if Coco hadn't contributed with over a million admission during the calendar year. Despite this, this year saw another movie claim the all-time #1: Infinity War reaped the steady growth of the MCU over the course of the decade, breaking every OD and OW record on sight. Total Admissions: 28.067.303 (+1,2%) Number of Screens: 472 Top Movie: Avengers Infinity War (2.334.956) Over 1m: 7; Infinity War, Incredibles 2 (1,8m), Jurassic World Fallen Kingdom (1,4m), Hotel Transylvania 3 (1,3m), Deadpool (1m), Bohemian Rhapsody (1m), The Nun (1m) Also notable: Bohemian Rhapsody was a huge succes, while Ferdinand at 9th (was 38th! domestically in 2017) is nothing short of impressive considering it had to deal with Coco of all things. 2019 The decade ends with a Book End, the same as it started: Toy Story at the top, this time claiming the all-time crown. 2019 was wild in every sense of the world. First Endgame broke all OW records again with numbers that pushed the market capacity at its limit, only to be defeated by the Winter's Holidays-powered, beloved Pixar film, with both movies breaking the 3 million admission milestone for the first time ever. The Lion King success also means that the all-time top 3 is entirely made of 2019 movies. This year ended the stagnation and was on track to a 10% growth until the social unrest that started in October closed cinemas for 13 days and depressed the BO for another 2 months. Things have calmed somewhat, but the future remains very uncertain. Total Admissions: 29.500.000 (+5,1%) (provisional) Number of Screens: ?? Top Movie: Toy Story 4 (3.190.000) Over 1m: 7; Toy Story 4, Avengers Endgame (3m), The Lion King (2,4m), Joker (1,5m), Captain Marvel (1,3m), Spiderman Far From Home (1m), How to Train Your Dragon 3 (1m) Also notable: Dragon Ball Super Broly (11th) broke the animated OW record in summer to the shock of everyone, becoming the most viewed non-US foreign movie of all time. The Joker also broke the all-time record for a +14 movie and would have touched 2m admission without the unrest.

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