I don't see how it discredits my argument. There's of course always the chance a movie will suck even if it does take risks. That's art in general. But Fox has been two for three in terms of their more genre-bending CBMs. Not to mention, Fantastic Four had a notoriously disastrous production, with a lot of butting heads and a hard to work with director. Obviously, we won't know how good the film is and whether production ran smoothly or not until months later, but Boone has been able to pull off a well-received film before, and while he hasn't done anything horror-related, he seems like a trustworthy director.
Also, Fantastic Four was only given studio meddling because of negative fan feedback and a douchey director. Deadpool and Logan were made with little interference, at least to my knowledge, and production ran smoothly and obviously were big moneymakers. I see little reason why New Mutants will be any different unless Boone is a douche to work with or fans feel the horror elements are against what NM stands for.
¯\_(ツ)_/¯