Yes, they will. This is very unfair. I won't be surprised if TFIOS surpass it next week, since in here this film just became another twilight. And it will be the only option at night, which is usually the time that people go to the movies.
And about the "weekdays", they simply don't exist. Filme B only show the numbers of the weekends.
I love how the budget is high, but the box office of the first movie already payed for it, and it still have additional 2 billion dollars.
James Cameron will do nothing but profit money with this franchise. Even if it does not reach to the same numbers as the first. (what is likely to happen, because at the time the film was released the tickets were more expensive)