I think it's different enough from the Incredibles that there isn't going to be much of a comparison. The visual style based on the art we've seen is vastly different at the very least.
It's being produced through ABC and Marvel Studios to Netflix, I believe, so it's a safe bet it's in the MCU until otherwise stated.
This is kind of a groundbreaking deal for Netflix though. They've done original series before but nothing even close to something like this.
Apparently it had good enough ratings for Marvel to move forward with FIVE NEW SHOWS.
http://www.deadline.com/2013/10/marvel-preps-60-episode-package-of-four-series-a-mini-for-vod-cable-networks/
It's ratings seem to be good enough that it should probably get renewed. well considering it's up against both the Voice and NCIS. It's getting good overseas ratings as well, though I don't know how much those factor in. ABC from all reports is very happy with the current ratings so I bet this'll do fine.
I think it goes without saying Iron Man 3 is going to do pretty well in China now. Apparently a tabloid newspaper in China said it'd be filimng there, and the main villlain is the Mandarin, but that Marvel's going to film it so that it doesn't portray China as a villain, just that the villain has origins from there.