I actually think it has a very small possibility for $200M+, but the last Dreamworks movie to accomplish that was Madagascar 3, so if CU opens over $60M, which is unlikely, it can happen.
CA3 also dealt with Angry Birds (and to a lesser extent Neighbors 2 and Nice Guys). AOU seems a better comparison, but I don't see Pirates under X-Men.
In terms of summer releases I know it's crazy but does anyone see a possibility where animated movies in the domestic box office is this:
DM3 ($275M-$300M) > CU ($165M-$200M) = C3 ($155M-$200M) > Emoji ($85M-$140M)
I think the fact that the GA needed to know about 6-7 films beforehand hurt Civil War the most, henceforth a rush factor OW, and then poor legs because the GA flocked OW.