They already said they're pulling the non-exclusive Disney stuff from Netflix (so yes to Civil War and Ragnarok leaving but not Daredevil or Punisher), and already announced there's a (unnamed) show on the service. Feige's more or less said he's not interested in mid-budget blockbusters (at least under the main banner), so I doubt we'll see stuff like original films there. We'll get the movies released on there for sure, but as far as originals I think that'll be mostly from the TV side.
Thirty bucks says Hannah John-Kamen returns as The Ghost for this one. With her being part of SHIELD and this being a prequel I'm almost certain it'll happen.
Also the obvious ones like Renner, Jackson, and Gregg.