Saw it last night, and I have to say I am one who is walking in that knows literally zero about this as I don't follow marvel or any of that stuff. For me, this was really solid: it had lots of humor, great action scenes, good characters (which Reynolds I thought knocked Wade out of the park), and pace wise I thought the film moved swiftly and always had your attention.
I think my only negative were two things: One was how he became a "super" powered human, Francis made a comment that the whole torture things he was going through actually wouldn't do anything to cure him, which made me think they scammed him. So, when Wade did have powers I was a bit confused, and I'm still confused as to how again. Like, did they discover enough stress will make a person somehow become incredibly super powered? My second was the villain Francis, I just didn't buy him being the "main" evil villain. I could buy him maybe being an underling (which in the beginning of the movie Deadpool kicked his ass easily), but somehow Francis is this big powerful enemy and for some reason I just didn't buy into him.
Other than hang those two minor things I can say I definitely like this movie and will want to see it again, and definitely will buy it when it comes out on DVD. It also was really refreshing to have some R rated jokes and raunchiness in a superhero flick. I gave this movie an A, overall 8.5/10.