I'm about to say something that may be insulting, but I think it needs to be said.
MMXXL is a perfect example of why Hollywood don't make many movies geared toward women. By the way I'm a woman too.
This movie was projected to make $40-$45 million over 5 days, now it will be lucky to make $30 million.
We women are so unpredictable, that Hollywood is afraid of us.
After Pitch Perfect 2, Hollywood was more than happy to make more movies for women, but after a movie like Spy (another movie where the b/o came in below expectation) and now MMXXL, Hollywood may not be so eager now to make women center movies.
On the other hand, men are very predictable, which is why 90% of movies (99% of summer movies) are geared toward them.