I thought Will Caster was going to go evil and all but not once in the entirety of the movie does he do anything approaching something that justifies taking him down. I mean, sure, injecting himself into people he's healing is a little creepy but after the first guy they all volunteer and like they aren't doing anything nefarious. There's literally no reason for any of them to oppose him and the movie fails to give anyone a reason to doubt him out of "'just cause".
So basically the movie is about humanity taking down a good computer. I guess the theme was supposed to be humanity's relationship with machines or how we fear the unknown but....nothing really interesting came out of this. Finally the movie decided to tell us the end in the beginning which sort of means there's no tension whatsoever, no way to anticipate what might happen, and therefore the stakes are flatlined. We know the outcome. Sure, movies are about the journey and not the destination but part of the journey is often going along. The fun of the journey is usually gone when you start and end in the same place: the destination.
Hopefully Wally Pfister gets to make more movies though. I think that the cinematography was top-notch, there was good acting, and a lot of sequences had good editing.
D+