Well I am from the UK and I can say I have been in quite a few screenings with a interactive audience.
When I saw Spider-man 3, the scene with the secretary consistently reminding J. Jameson of his medications with the buzzer, had people literally screaming with laughter and then received a round of applause and a standing ovation.
The scene in Fast and Furious 6, when Vin saves Michelle by doing a superman, received a huge laugh and clapping as well as the reveal of Statham which got a standing ovation.
PA1 infamous leg drag scene made the audience scream so loud I can still hear the ringing in my ear.
Deathly Hallows Part 2 got several claps and a huge 'awwwwwwwwww' at the final scene with the trio looking at the train leaving the station.
The reveal of the girl killer in Scream 4 received a huge laugh and her self-mutilation scene caused a laughing riot.
The Da Vinci Code's reveal of the long distant relation to Jesus Christ received several laughs.
The worst reaction I have ever witnessed was during Van Helsing which received several boos and someone shouting 'this is shit'