Seems like it would be very easy to just ignore it going forward. I don't see why doing an explicit wipe is necessary at all.
The Batgirl and Supergirl stuff is whatever to me, I like the individual DC movies decently (Aquaman, Wonder Woman, Shazam, TSS etc.) but am not invested in the shared universe at all atm, so whoever leads the Justice League is sort of immaterial to my enjoyment. Still it does feel kinda...odd, like a desperate move to feel "new." Like I don't see a reason why those characters couldn't exist alongside new incarnations of Batman and Superman.